Industries
Services

Pharmaceutical & Biopharmaceutical Development Services

EAG brings unparalleled expertise to the development and commercialization of small molecule drugs, biopharmaceuticals, antibody-drug conjugates (ADCs), drug-device combination…

EAG brings unparalleled expertise to the development and commercialization of small molecule drugs, biopharmaceuticals, antibody-drug conjugates (ADCs), drug-device combination products and other therapies. From designing IND-enabling studies to delivering full CMC analytical and QC support, we join your R&D team as a true partner. EAG scientists take time to understand both your commercial goals and the unique characteristics of your compound. We provide expert guidance to balance regulatory expectations with expediency and cost, and approach technical challenges with flexibility and resolve.

Materials Testing & Analysis

When it comes to understanding the physical structure, chemical properties and composition of materials, no scientific services company offers the breadth of experience, diversity…

When it comes to understanding the physical structure, chemical properties and composition of materials, no scientific services company offers the breadth of experience, diversity of analytical techniques of technical ingenuity of EAG. From polymers to composites, thin films to superalloys—we know how to leverage materials sciences to gain a competitive edge. At EAG, we don’t just perform testing, we drive commercial success—through thoughtfully designed investigations, technically superior analyses and expert interpretation of data.

Environmental Testing & Regulatory Compliance

Having helped develop the test methods that shape current regulatory guidelines, EAG chemists, biologists and toxicologists have evaluated the environmental impact of thousands of…

Having helped develop the test methods that shape current regulatory guidelines, EAG chemists, biologists and toxicologists have evaluated the environmental impact of thousands of active ingredients and formulations—from pesticides and pharmaceuticals to industrial chemicals and consumer products. Whether you are exploring “what if” scenarios, registering a new active ingredient or formulation, responding to a data call-in or seeking to understand the latest guidance, turn to EAG for technical excellence, sound advice, GLP-compliant study execution and expert interpretation.

Microelectronics Test & Engineering

Whether connecting the internet of things, guiding surgical lasers or powering the latest smart phone, integrated circuits and microelectronics touch nearly every aspect of human…

Whether connecting the internet of things, guiding surgical lasers or powering the latest smart phone, integrated circuits and microelectronics touch nearly every aspect of human life. In the world of technology, innovation and continuous improvement are imperatives—and being able to quickly and reliably test, debug, diagnose failures and take corrective action can make the difference between a doomed product launch and building a successful global brand. EAG offers you the world’s largest and most diverse collection of specialized analytical instrumentation, capacity to perform a variety of microelectronic tests in parallel, and the multi-disciplinary expertise required to draw true insight from data.

Custom Synthesis & Radiolabeling

No contract service provider has more experience performing custom synthesis and producing isotopically labeled compounds to support product development in life science, chemical…

No contract service provider has more experience performing custom synthesis and producing isotopically labeled compounds to support product development in life science, chemical and related industries than we do. From 14C and 3H radiolabeled clinical trial materials synthesized under cGMP, to stable-labeled active ingredients for metabolism and environmental fate/effects testing, turn to EAG. We have extensive experience with multi-step and other complex synthesis projects, and our comprehensive, in-house analytical services ensure quick turnaround of purity and structural confirmation.

Crop Biotechnology & Development

EAG combines biotechnology and protein characterization expertise with more than 50 years' experience analyzing chemical compounds in plant and environmental matrices to address…

EAG combines biotechnology and protein characterization expertise with more than 50 years’ experience analyzing chemical compounds in plant and environmental matrices to address the growing needs of the biotechnology crop industry. We offer a wide range of techniques required to fully characterize the event insertion and expressed proteins, as well as the various studies required to confirm the food, feed and environmental safety of products that represent the trait. From early-stage protein confirmation to GLP-compliant EDSP and allergenicity testing, we help you make faster, more informed development decisions and comply with evolving global regulations of genetically engineered crops.

Litigation Support & Expert Testimony

When you need solid science and investigative engineering to address product failures, inform legal strategy, protect intellectual property or address product liability disputes,…

When you need solid science and investigative engineering to address product failures, inform legal strategy, protect intellectual property or address product liability disputes, turn to EAG. We’ve provided technical consulting, analysis and expert testimony for hundreds of cases involving the aerospace, transportation, medical device, electronics, industrial and consumer product industries. Our team of experts understands the legal process and your need for responsiveness, effective communication, scientifically defensible opinion and confidentiality. From professional consulting to data review to trial preparation and expert witness testimony, ask EAG.

Techniques

Chromatography

Using an array of advanced separation techniques and innovative technology, we conduct highly precise analytical chromatography for various industries. Whether you want a closer…

Using an array of advanced separation techniques and innovative technology, we conduct highly precise analytical chromatography for various industries. Whether you want a closer look at the purity of your pharmaceutical or need to better understand an agrochemical’s components, EAG has the expertise to separate and evaluate any compound.

Mass Spectrometry

Need to evaluate the molecular structure of a compound or identify its origins? EAG knows how. With state-of-the-art tools, we can separate, vaporize and ionize the atoms and…

Need to evaluate the molecular structure of a compound or identify its origins? EAG knows how. With state-of-the-art tools, we can separate, vaporize and ionize the atoms and molecules in almost any pure or complex material to detect and obtain mass spectra of the components. We rely on decades of experience in mass spectrometry to provide our clients with precise analyses and the best detection limits.

Imaging

EAG is a world leader in high-resolution imaging down to the atomic level. We offer unmatched analytical know-how, generating extremely detailed surface and near surface images…

EAG is a world leader in high-resolution imaging down to the atomic level. We offer unmatched analytical know-how, generating extremely detailed surface and near surface images for various industries, from consumer electronics to nanotechnology. Using state-of-the-art equipment and innovative techniques, we conduct expert imaging to aid in failure analysis, dimensional analysis, process characterization, particle identification and more. If you want to investigate a material with angstrom scale resolution, you can count on EAG to get the job done quickly and precisely.

Spectroscopy

EAG offers a vast array of spectroscopic techniques to clients in various industries, from defense contractors to technology pioneers. We combine unparalleled expertise and…

EAG offers a vast array of spectroscopic techniques to clients in various industries, from defense contractors to technology pioneers. We combine unparalleled expertise and methodology with cutting-edge technology to analyze your organic, inorganic, metallic and composite materials for identification, compositional, structural and contaminant information. Whether you need expert spectroscopic analysis to improve your production process or to surmount a technical challenge, EAG is up to the task.

Physical/Chemical Characterization

Need to identify your unique material? Want to analyze the thermal properties of a sample, or measure the success of a process step? If it has to be done quickly and it has to be…

Need to identify your unique material? Want to analyze the thermal properties of a sample, or measure the success of a process step? If it has to be done quickly and it has to be done right, you can count on EAG. We offer a range of adaptable techniques and innovative methods to evaluate the physical and chemical characteristics of any compound. Our highly precise testing and analytical services will improve your production process, expedite R&D and help you conquer any technical challenge.

About

A Global Scientific Services Company

One of the most respected names in contract research and testing, EAG Laboratories is a global scientific services company operating at the intersection of science, technology and…

One of the most respected names in contract research and testing, EAG Laboratories is a global scientific services company operating at the intersection of science, technology and business. The scientists and engineers of EAG apply multi-disciplinary expertise, advanced analytical techniques and “we know how” resolve to answer complex questions that drive commerce around the world.

Our Customers

Science and technology transcend industry boundaries, and so does demand for EAG’s expertise. We partner with companies across a broad spectrum of high-tech, high-impact and…

Science and technology transcend industry boundaries, and so does demand for EAG’s expertise. We partner with companies across a broad spectrum of high-tech, high-impact and highly regulated industries. We help our customers innovate new and improved products, investigate manufacturing problems, perform advanced analyses to determine safety, efficacy and regulatory compliance, and protect their brands.

Our Company Culture

EAG’s corporate culture is firmly rooted in four guiding principles: “foster a growth mindset,” “find a better way,” “earn more loyal customers,” and “win…

EAG’s corporate culture is firmly rooted in four guiding principles: “foster a growth mindset,” “find a better way,” “earn more loyal customers,” and “win together.” Across all of our 20+ locations, you will find a true passion for science and the power of science to improve the world we live in. Hear what some of our ~1200 scientists, engineers and support personnel say about what it means to be part of EAG Laboratories.

Careers

EAG is growing, and we are always looking for talented, problem-solving oriented individuals to join our company. If you have a “we know how” spirit, we want to hear from you.…

EAG is growing, and we are always looking for talented, problem-solving oriented individuals to join our company. If you have a “we know how” spirit, we want to hear from you. Browse current openings now, and re-visit our careers page often.

How do you make continuous improvement profitable?

Characterizing Catalysts to Enhance R&D Efficiency

WHITE PAPER

INTRODUCTION

Catalysts are essential to the manufacture of many products ranging from fuels and chemicals, to plastics and pharmaceuticals. Catalysts are required to facilitate the chemical reactions needed to create the desired products. Continuous advances are being made in catalysis and how catalysts work to best optimize these transformations.

There are several techniques that can provide a wealth of information about heterogeneous catalysis, allowing for detailed characterization of these potentially complicated materials. These techniques can aid researchers and scientists involved in R&D to better optimize their processes and carry out product development in the most efficient, economical, and environmentally responsible manner. Some of the more common techniques used for characterizing these materials include:

SCANNING TRANSMISSION ELECTRON MICROSCOPY (STEM) AND TRANSMISSION ELECTRON MICROSCOPY (TEM)

STEM and TEM are related techniques that can provide ultrahigh resolution images of features, layers and particles. STEM-EDS (Energy Dispersive X-ray Spectroscopy) is also capable of performing elemental analysis on the scale of a few nm, which is ideal for determining the elemental constituents of individual metal catalyst particles.

In both STEM and TEM an electron beam is incident on an ultrathin sample and the transmitted electrons are detected. Many signals can be detected by the technique including: unscattered electrons, diffracted electrons, incoherently scattered electrons, x-rays and finally electron energy loss. All of these signals can provide valuable information including elemental identification/distribution; phase identification and feature size. These techniques can have an image resolution of <0.2 nm. EAG has extensive preparation capabilities including low energy FIB methods and mechanical methods enabling the investigation of materials that are otherwise hard to prepare. Figure 1 shows CdSe/ZnS core/shell nanoparticles with a diameter of 7 nm. Figure 2 shows an EDS map of silicon covered gold nanoparticles.

Figure 1 TEM image of CdSe/ZnS nanoparticles

Figure 2 Au (red)/Si (green) elemental map

X-RAY PHOTOELECTRON SPECTROSCOPY (XPS)

X-ray Photoelectron Spectroscopy (XPS) also known as Electron Spectroscopy for Chemical Analysis (ESCA) can provide quantitative chemical analysis of the top ~10nm of a surface. XPS can easily characterize insulating and conductive samples from areas >50µm. XPS is capable of providing “chemical state” information on a sample. Figure 3 shows the chemical state identification of carbon in two locations on a fluorine-containing material. In one area, only carbon-oxygen functionality is observed; in the second area carbon-fluorine chemistry is detected. Chemical State information can be obtained for almost all elements, including whether they are present as a metal or metal oxide. XPS is a valuable tool for the investigation of catalyst aging, recovery and poisoning because it is capable of quantification, chemical state identification and analysis of insulators.

Figure 3 High resolution XPS spectra of carbon chemistries

X-RAY DIFFRACTION (XRD)

X-ray Diffraction (XRD) utilizes an x-ray beam to provide a wide range of crystallographic information. Data regarding crystallinity, phase, crystallite size, strain and phase quantification are routinely obtained by XRD. XRD is a widely used characterization technique for catalysts, to study changes in crystallite size, strain and phase after aging of active catalyst material. Figure 4(a) shows how the different components of XRD data can be used to measure various properties of the sample. Figure 4(b) shows the sensitivity of XRD to determine changes in crystallite size.

Figure 4 XRD data can provide information regarding: Phase, Stress, Cystallite size, strain and texture

WAVELENGTH DISPERSIVE X-RAY FLUORESCENCE (WD-XRF)

Wavelength Dispersive X-ray Fluorescence (WD-XRF) provides quantitative measurements of the elements present in a sample, with excellent accuracy. WD-XRF is a high resolution XRF technique that provides excellent detection limits and does not suffer from the same potential interferences found in the more common Energy Dispersive technique (ED-XRF). The detection limit for many elements by WD-XRF can be up to 100x better than ED-XRF (down to the 10ppm range). Figure 5 shows calculated spectra from a multi component oxide, demonstrating the excellent spectral resolution of the WD-XRF.

Figure 5 Calculated spectra from WD-XRF and standard ED-XRF. The spectral resolution of WD-XRF greatly improves sensitivity and element identification capability.

GLOW DISCHARGE MASS SPECTROMETRY (GDMS)

Glow Discharge Mass Spectrometry (GDMS) provides elemental information on bulk materials and powders, including non-conductive materials, with minimum sample preparation, over a broad concentration range, from 100% down to trace levels. The limit of detection for many elements can be 5ppb or less.

This technique is a great complement to the more common ICP techniques, but with better detection limits and no solution sample preparation artifacts that may occur due to the dissolution process necessary in ICP. In conjunction with GDMS we also provide IGA (Instrumental Gas Analysis) for the quantification of carbon, hydrogen nitrogen, oxygen and sulfur.

Table 1 IGA results from an Aluminum sample

Table 2 GDMS from a Ta sample; On average, the limit of quantification is 5ppb

LEVERAGING INDEPENDENT LAB ANALYSIS IN R&D

Using an experienced independent analytical lab to characterize your materials can speed your development cycle and reduce the time to market for commercial products. Detailed characterization of catalysts through the use of various techniques is an important step in R&D. EAG Laboratories is a global scientific services company founded on a deep tradition of excellence and passionate customer service to high-growth, high-tech industries.

EAG Laboratories has a 35 year history of supporting materials development for technology and industrial companies. EAG Laboratories also helps with product development, by analyzing samples using a wide range of analytical techniques. Many of our staff have advanced degrees in subjects including materials science, geology, physics, chemistry, and biology, providing our customers with a wide range of expertise to draw on. In addition to our expert staff, we have over $75M invested in capital equipment and tools used for analysis. ISO Certification (9001 and 17025), and secure intellectual property protection and excellent turnaround times provide exceptional value to our customers.

EAG Laboratories offers a wide range of techniques that are of interest to the catalysis and nanoparticle R&D community. In addition to the analysis techniques discussed in this paper, we also provide ICP-MS, ICP-OES, DSC, TGA, TGA-MS and many other measurements to help our clients meet their goals.