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Pharmaceutical & Biopharmaceutical Development Services

EAG brings unparalleled expertise to the development and commercialization of small molecule drugs, biopharmaceuticals, antibody-drug conjugates (ADCs), drug-device combination…

EAG brings unparalleled expertise to the development and commercialization of small molecule drugs, biopharmaceuticals, antibody-drug conjugates (ADCs), drug-device combination products and other therapies. From designing IND-enabling studies to delivering full CMC analytical and QC support, we join your R&D team as a true partner. EAG scientists take time to understand both your commercial goals and the unique characteristics of your compound. We provide expert guidance to balance regulatory expectations with expediency and cost, and approach technical challenges with flexibility and resolve.

Materials Testing & Analysis

When it comes to understanding the physical structure, chemical properties and composition of materials, no scientific services company offers the breadth of experience, diversity…

When it comes to understanding the physical structure, chemical properties and composition of materials, no scientific services company offers the breadth of experience, diversity of analytical techniques of technical ingenuity of EAG. From polymers to composites, thin films to superalloys—we know how to leverage materials sciences to gain a competitive edge. At EAG, we don’t just perform testing, we drive commercial success—through thoughtfully designed investigations, technically superior analyses and expert interpretation of data.

Environmental Testing & Regulatory Compliance

Having helped develop the test methods that shape current regulatory guidelines, EAG chemists, biologists and toxicologists have evaluated the environmental impact of thousands of…

Having helped develop the test methods that shape current regulatory guidelines, EAG chemists, biologists and toxicologists have evaluated the environmental impact of thousands of active ingredients and formulations—from pesticides and pharmaceuticals to industrial chemicals and consumer products. Whether you are exploring “what if” scenarios, registering a new active ingredient or formulation, responding to a data call-in or seeking to understand the latest guidance, turn to EAG for technical excellence, sound advice, GLP-compliant study execution and expert interpretation.

Microelectronics Test & Engineering

Whether connecting the internet of things, guiding surgical lasers or powering the latest smart phone, integrated circuits and microelectronics touch nearly every aspect of human…

Whether connecting the internet of things, guiding surgical lasers or powering the latest smart phone, integrated circuits and microelectronics touch nearly every aspect of human life. In the world of technology, innovation and continuous improvement are imperatives—and being able to quickly and reliably test, debug, diagnose failures and take corrective action can make the difference between a doomed product launch and building a successful global brand. EAG offers you the world’s largest and most diverse collection of specialized analytical instrumentation, capacity to perform a variety of microelectronic tests in parallel, and the multi-disciplinary expertise required to draw true insight from data.

Custom Synthesis & Radiolabeling

No contract service provider has more experience performing custom synthesis and producing isotopically labeled compounds to support product development in life science, chemical…

No contract service provider has more experience performing custom synthesis and producing isotopically labeled compounds to support product development in life science, chemical and related industries than we do. From 14C and 3H radiolabeled clinical trial materials synthesized under cGMP, to stable-labeled active ingredients for metabolism and environmental fate/effects testing, turn to EAG. We have extensive experience with multi-step and other complex synthesis projects, and our comprehensive, in-house analytical services ensure quick turnaround of purity and structural confirmation.

Crop Biotechnology & Development

EAG combines biotechnology and protein characterization expertise with more than 50 years' experience analyzing chemical compounds in plant and environmental matrices to address…

EAG combines biotechnology and protein characterization expertise with more than 50 years’ experience analyzing chemical compounds in plant and environmental matrices to address the growing needs of the biotechnology crop industry. We offer a wide range of techniques required to fully characterize the event insertion and expressed proteins, as well as the various studies required to confirm the food, feed and environmental safety of products that represent the trait. From early-stage protein confirmation to GLP-compliant EDSP and allergenicity testing, we help you make faster, more informed development decisions and comply with evolving global regulations of genetically engineered crops.

Litigation Support & Expert Testimony

When you need solid science and investigative engineering to address product failures, inform legal strategy, protect intellectual property or address product liability disputes,…

When you need solid science and investigative engineering to address product failures, inform legal strategy, protect intellectual property or address product liability disputes, turn to EAG. We’ve provided technical consulting, analysis and expert testimony for hundreds of cases involving the aerospace, transportation, medical device, electronics, industrial and consumer product industries. Our team of experts understands the legal process and your need for responsiveness, effective communication, scientifically defensible opinion and confidentiality. From professional consulting to data review to trial preparation and expert witness testimony, ask EAG.

Techniques

Chromatography

Using an array of advanced separation techniques and innovative technology, we conduct highly precise analytical chromatography for various industries. Whether you want a closer…

Using an array of advanced separation techniques and innovative technology, we conduct highly precise analytical chromatography for various industries. Whether you want a closer look at the purity of your pharmaceutical or need to better understand an agrochemical’s components, EAG has the expertise to separate and evaluate any compound.

Mass Spectrometry

Need to evaluate the molecular structure of a compound or identify its origins? EAG knows how. With state-of-the-art tools, we can separate, vaporize and ionize the atoms and…

Need to evaluate the molecular structure of a compound or identify its origins? EAG knows how. With state-of-the-art tools, we can separate, vaporize and ionize the atoms and molecules in almost any pure or complex material to detect and obtain mass spectra of the components. We rely on decades of experience in mass spectrometry to provide our clients with precise analyses and the best detection limits.

Imaging

EAG is a world leader in high-resolution imaging down to the atomic level. We offer unmatched analytical know-how, generating extremely detailed surface and near surface images…

EAG is a world leader in high-resolution imaging down to the atomic level. We offer unmatched analytical know-how, generating extremely detailed surface and near surface images for various industries, from consumer electronics to nanotechnology. Using state-of-the-art equipment and innovative techniques, we conduct expert imaging to aid in failure analysis, dimensional analysis, process characterization, particle identification and more. If you want to investigate a material with angstrom scale resolution, you can count on EAG to get the job done quickly and precisely.

Spectroscopy

EAG offers a vast array of spectroscopic techniques to clients in various industries, from defense contractors to technology pioneers. We combine unparalleled expertise and…

EAG offers a vast array of spectroscopic techniques to clients in various industries, from defense contractors to technology pioneers. We combine unparalleled expertise and methodology with cutting-edge technology to analyze your organic, inorganic, metallic and composite materials for identification, compositional, structural and contaminant information. Whether you need expert spectroscopic analysis to improve your production process or to surmount a technical challenge, EAG is up to the task.

Physical/Chemical Characterization

Need to identify your unique material? Want to analyze the thermal properties of a sample, or measure the success of a process step? If it has to be done quickly and it has to be…

Need to identify your unique material? Want to analyze the thermal properties of a sample, or measure the success of a process step? If it has to be done quickly and it has to be done right, you can count on EAG. We offer a range of adaptable techniques and innovative methods to evaluate the physical and chemical characteristics of any compound. Our highly precise testing and analytical services will improve your production process, expedite R&D and help you conquer any technical challenge.

About

A Global Scientific Services Company

One of the most respected names in contract research and testing, EAG Laboratories is a global scientific services company operating at the intersection of science, technology and…

One of the most respected names in contract research and testing, EAG Laboratories is a global scientific services company operating at the intersection of science, technology and business. The scientists and engineers of EAG apply multi-disciplinary expertise, advanced analytical techniques and “we know how” resolve to answer complex questions that drive commerce around the world.

Our Customers

Science and technology transcend industry boundaries, and so does demand for EAG’s expertise. We partner with companies across a broad spectrum of high-tech, high-impact and…

Science and technology transcend industry boundaries, and so does demand for EAG’s expertise. We partner with companies across a broad spectrum of high-tech, high-impact and highly regulated industries. We help our customers innovate new and improved products, investigate manufacturing problems, perform advanced analyses to determine safety, efficacy and regulatory compliance, and protect their brands.

Our Company Culture

EAG’s corporate culture is firmly rooted in four guiding principles: “foster a growth mindset,” “find a better way,” “earn more loyal customers,” and “win…

EAG’s corporate culture is firmly rooted in four guiding principles: “foster a growth mindset,” “find a better way,” “earn more loyal customers,” and “win together.” Across all of our 20+ locations, you will find a true passion for science and the power of science to improve the world we live in. Hear what some of our ~1200 scientists, engineers and support personnel say about what it means to be part of EAG Laboratories.

Careers

EAG is growing, and we are always looking for talented, problem-solving oriented individuals to join our company. If you have a “we know how” spirit, we want to hear from you.…

EAG is growing, and we are always looking for talented, problem-solving oriented individuals to join our company. If you have a “we know how” spirit, we want to hear from you. Browse current openings now, and re-visit our careers page often.

How do you constantly innovate while driving down costs?

PCOR-SIMS Analysis of GaN HEMT Epitaxial Layers Grown on Silicon Substrates

WHITE PAPER

AlGaN/GaN heterostructure field-effect transistors (HFETs) have been a subject of intense research and are now coming into production for use in high-voltage, high-power operation at microwave frequencies. Compared to similar devices made from GaAs-based materials, GaN has a larger peak electron velocity, higher thermal stability, and a larger band gap, all of which are very suitable as a channel material in microwave power devices. Further contributing to the performance of AlGaN/GaN-based HFETs is the ability to form two-dimensional electron gases (2DEG) with sheet carrier concentrations of 1013/cm2. These devices are more commonly referred to as High Electron Mobility Transistors (HEMTs).

An area of processing concern, however, is the substrate on which the 2DEG layers are grown. Growth on a GaN substrate would be ideal because of the exact lattice match between it and the layers being grown. This would mean that any GaN buffer layer grown to isolate the 2DEG from the substrate would not have to be very thick to avoid defects in the active region of the device. Unfortunately, GaN substrates cannot, at present, be grown in sufficiently large sizes to make them commercially viable from a cost standpoint. Therefore, alternative substrates must be used. Single-crystal SiC is being used because of its electrical and thermal-conductivity properties, but mainly because it is very closely lattice-matched to GaN (3%). However, it, too, is quite costly. Sapphire substrates are less expensive but have poorer thermal conductivity (a disadvantage for high-power devices) and have an even higher lattice mismatch with GaN (13%). Therefore, silicon is now drawing much attention as a potential substrate because of its large base of established manufacturing tools and processes. However, Si is very highly mismatched to GaN which promotes the growth of many defects in the GaN grown thereon. This requires thick buffer layers of AlGaN to be grown between the Si substrate and the 2DEG-forming layers to reduce the defect density in this region of the device. An example of this is shown in Figures 1 and 2.

Figure 1 Center and edge comparison of a HEMT epi measured by PCOR-SIMSSM.

Figure 1 shows a Point-by-Point Corrected SIMS (PCOR-SIMSSM) depth profile of a complete GaN HEMT structure grown on a 150mm-diameter Si wafer. (The 2DEG region of the structure is almost imperceptible at the surface but we will address that later.) In this example, the buffer layer begins with an AlN layer. This material is not well lattice-matched to the Si underneath but it provides an insulating layer to isolate the layers above from the substrate. The AlN also acts as a seed layer upon which to grow successive layers of AlGaN with successively lower Al levels. The decreasing Al content lowers the defect density to acceptable levels by the time the GaN barrier layer is grown, as shown in the bottom left TEM micrograph of the sample in Figure 2. Note that the PCOR-SIMSSM analysis measures the various Al and Ga atomic fractions and layer thicknesses accurately.

Figure 1 also shows that the bottom half of the GaN barrier layer is doped with carbon. This carbon doping compensates the unintentional n-type doping by impurities (mainly Si and O as shown in the figure) in the AlGaN buffer and increases the breakdown field strength. However, the figure shows that the carbon doping in the GaN portion of the buffer at the edge of the wafer is a factor of ten higher than in the center. This will have considerable implications on the electric field reduction properties of the barrier layer at different locations across the 150mm wafer. However, one can see that the carbon content, as well as layer thicknesses, of the buffer layers are more similar between the center and edge of the wafer. The carbon level (as well as the Si and O levels) in the barrier layer is important because excessively high levels will lead to leakage in the devices.

In the vicinity of the 2DEG, carbon doping was reported to promote vertical leakage current, to cause degradation of both carrier density and carrier mobility of the 2DEG channel electrons, and to increase the dynamic on-resistance and current collapse, all of which are detrimental for device performance and reliability. In spite of the detrimental character of carbon doping on 2DEG and device properties, few reports have dealt with the residual carbon level in the active layers (AlN spike and AlGaN barrier layer). This is perhaps because measuring carbon in this near-surface region is severely hampered by surface pits that are always present due to threading dislocations originating deep in the buffer layer (reaching the surface) (see Figure 2).

PCOR-SIMS - Figure 2 Cross-sectional TEM images of generation of surface pits (above) and the higher magnification of the details (below).
Figure 2 Cross-sectional TEM images of generation of surface pits (above) and the higher magnification of the details (below).

Carbon will become adsorbed on the air-exposed top surface and will not be entirely removed by the SIMS sputtering process until the entire pit is sputtered through. This artificially-deep carbon profile can totally obscure the real, important carbon distribution in the 2DEG region.

To circumvent this problem, we have developed a proprietary surface cleaning procedure that removes the vast majority of carbon from the surface thus eliminating the deep tail of the carbon profile (Figure 3). This allows us to measure the true carbon concentration in the AlGaN barrier layer just above the 2DEG as well as in the AlN spike just below the 2DEG.

PCOR-SIMS - Figure 3 SIMS profiles for C in the 2DEG region as-received (red) and after cleaning (blue).
Figure 3 SIMS profiles for C in the 2DEG region as-received (red) and after cleaning (blue).

The buffer layer can also be doped with Fe and Mg. These can also be measured by SIMS with very low detection limits (Figure 4). Note the peak in the Fe profile just inside the GaN barrier layer. This peak is not present at the edge of the wafer, thus pointing out another difficultly in growing uniform layers across large substrates.

PCOR-SIMS - Figure 4 Fe and Mg impurity SIMS measurements in HEMT epi.
Figure 4 Fe and Mg impurity SIMS measurements in HEMT epi.

It is also important to control non-metallic impurity levels in the GaN barrier layer. For example, the Si level must be as low as possible in the GaN directly below the 2DEG because the device functions in the absence of dopants. As shown in Figure 5, we can obtain Si detection limits in the mid 1014atom/cm3range; low enough to see the 2×1015atom/cm3 Si level just beneath the 2DEG.

Figure 5 also shows the levels of H impurities in the GaN barrier layer. Hydrogen can have deleterious effects on device reliability, so one tries to keep the H levels as low as possible. However, in this example, we see that the H level in the carbon-doped portion of the barrier layer is lightly elevated. This presumably arises from the source gas used for the carbon doping.

PCOR-SIMS - Figure 5 Low detection limit measurement of H and Si in GaN barrier layer of a HEMT epi.
Figure 5 Low detection limit measurement of H and Si in GaN barrier layer of a HEMT epi.

The region near the surface of the structure is where the 2DEG, which is responsible for the current flow in the device, is formed. The 2DEG forms here because of the conduction-band discontinuity between a thin, top-doped AlGaN layer and an undoped GaN layer. This creates a triangular quantum well in which electrons accumulate. This active region is exceedingly thin (20-30nm) and can be measured accurately by SIMS only with great care. Figure 6 shows a PCOR-SIMS profile showing the Al which locates the AlGaN top layer along with the C, H, O and Si impurity of the 2DEG-forming region of a HEMT.

PCOR-SIMS - Figure 6 Channel region higher depth resolution PCOR-SIMS profiling of a HEMT device.
Figure 6 Channel region higher depth resolution PCOR-SIMS profiling of a HEMT device.

Since this layer is on the top of the structure, it is important to take measures to minimize the effects of the surface contamination that is always present on these air-exposed surfaces. In Figure 6, the carbon initially present on the sample surface was removed using our proprietary surface cleaning procedure which allowed the carbon-doping level to be measured in the AlGaN layer at a level of 1-2×1017atoms/cm3 within the top 15nm of the sample.

Figure 6 also gives the device engineer another important piece of information—the thickness of the AlGaN barrier layer. This is the layer through which the potential on the gate must act to control the density of electrons in the 2DEG and thus the conductance of the device. This can be seen in the linear-plot inset in Figure 6.

Figure 7 shows selected profiles of Figure 6 plotted on a linear scale instead of a logarithmic one, overlaid on a cross sectional TEM micrograph of the same region. The Al profile shows the location of the AlN delta layer which is included in the structure to improve the carrier mobility in the 2DEG by mitigating Coulomb scattering from the donors in the AlGaN. We can see in the TEM micrograph that the actual width of the AlN delta layer is correctly measured by the full-width-half maximum (FWHM) of the Al profile above the constant level in the AlGaN layer, although the profile tails into the underlying GaN because of the surface pits shown in Figure 3.

PCOR-SIMS- Figure 7 Overlay of SIMS and cross-sectional TEM showing detailed analysis of HEMT channel region with an arbitrary conductivity change curve.
Figure 7 Overlay of SIMS and cross-sectional TEM showing detailed analysis of HEMT channel region with an arbitrary conductivity change curve.

The carbon profile is plotted to show the location of the doping with respect to the exact location of the interface (shown by the Al profile). TEM cannot be used to detect carbon, even with EDX (energy dispersive X-ray spectrometry) or EELS (electron energy loss spectroscopy).

In addition, we show a profile (red) that is affected by the instantaneous surface potential from which the surface conductivity can be inferred. The 2DEG is formed just inside the GaN, and we can see from the plot that this is the exact depth at which the sample conductivity recovers after the profile passes through a zone of decreased conductivity just inside the barrier layer where the holes accumulate.

In conclusion, we have shown how Point-by-Point Corrected SIMS (PCOR-SIMS) can be used to determine accurate concentrations of matrix elements and dopants in GaN HEMTs and how these results can be of use in optimizing epitaxial layer growth and in failure analysis. If you have any questions, please feel free to contact EAG with your GaN HEMT analytical needs.