Industries
Services

Pharmaceutical & Biopharmaceutical Development Services

EAG brings unparalleled expertise to the development and commercialization of small molecule drugs, biopharmaceuticals, antibody-drug conjugates (ADCs), drug-device combination…

EAG brings unparalleled expertise to the development and commercialization of small molecule drugs, biopharmaceuticals, antibody-drug conjugates (ADCs), drug-device combination products and other therapies. From designing IND-enabling studies to delivering full CMC analytical and QC support, we join your R&D team as a true partner. EAG scientists take time to understand both your commercial goals and the unique characteristics of your compound. We provide expert guidance to balance regulatory expectations with expediency and cost, and approach technical challenges with flexibility and resolve.

Materials Testing & Analysis

When it comes to understanding the physical structure, chemical properties and composition of materials, no scientific services company offers the breadth of experience, diversity…

When it comes to understanding the physical structure, chemical properties and composition of materials, no scientific services company offers the breadth of experience, diversity of analytical techniques or technical ingenuity of EAG. From polymers to composites, thin films to superalloys—we know how to leverage materials sciences to gain a competitive edge. At EAG, we don’t just perform testing, we drive commercial success—through thoughtfully designed investigations, technically superior analyses and expert interpretation of data.

Environmental Testing & Regulatory Compliance

Having helped develop the test methods that shape current regulatory guidelines, EAG chemists, biologists and toxicologists have evaluated the environmental impact of thousands of…

Having helped develop the test methods that shape current regulatory guidelines, EAG chemists, biologists and toxicologists have evaluated the environmental impact of thousands of active ingredients and formulations—from pesticides and pharmaceuticals to industrial chemicals and consumer products. Whether you are exploring “what if” scenarios, registering a new active ingredient or formulation, responding to a data call-in or seeking to understand the latest guidance, turn to EAG for technical excellence, sound advice, GLP-compliant study execution and expert interpretation.

Microelectronics Test & Engineering

Whether connecting the internet of things, guiding surgical lasers or powering the latest smart phone, integrated circuits and microelectronics touch nearly every aspect of human…

Whether connecting the internet of things, guiding surgical lasers or powering the latest smart phone, integrated circuits and microelectronics touch nearly every aspect of human life. In the world of technology, innovation and continuous improvement are imperatives—and being able to quickly and reliably test, debug, diagnose failures and take corrective action can make the difference between a doomed product launch and building a successful global brand. EAG offers you the world’s largest and most diverse collection of specialized analytical instrumentation, capacity to perform a variety of microelectronic tests in parallel, and the multi-disciplinary expertise required to draw true insight from data.

Custom Synthesis & Radiolabeling

No contract service provider has more experience performing custom synthesis and producing isotopically labeled compounds to support product development in life science, chemical…

No contract service provider has more experience performing custom synthesis and producing isotopically labeled compounds to support product development in life science, chemical and related industries than we do. From 14C and 3H radiolabeled clinical trial materials synthesized under cGMP, to stable-labeled active ingredients for metabolism and environmental fate/effects testing, turn to EAG. We have extensive experience with multi-step and other complex synthesis projects, and our comprehensive, in-house analytical services ensure quick turnaround of purity and structural confirmation.

Crop Biotechnology & Development

EAG combines biotechnology and protein characterization expertise with more than 50 years' experience analyzing chemical compounds in plant and environmental matrices to address…

EAG combines biotechnology and protein characterization expertise with more than 50 years’ experience analyzing chemical compounds in plant and environmental matrices to address the growing needs of the biotechnology crop industry. We offer a wide range of techniques required to fully characterize the event insertion and expressed proteins, as well as the various studies required to confirm the food, feed and environmental safety of products that represent the trait. From early-stage protein confirmation to GLP-compliant EDSP and allergenicity testing, we help you make faster, more informed development decisions and comply with evolving global regulations of genetically engineered crops.

Litigation Support & Expert Testimony

When you need solid science and investigative engineering to address product failures, inform legal strategy, protect intellectual property or address product liability disputes,…

When you need solid science and investigative engineering to address product failures, inform legal strategy, protect intellectual property or address product liability disputes, turn to EAG. We’ve provided technical consulting, analysis and expert testimony for hundreds of cases involving the aerospace, transportation, medical device, electronics, industrial and consumer product industries. Our team of experts understands the legal process and your need for responsiveness, effective communication, scientifically defensible opinion and confidentiality. From professional consulting to data review to trial preparation and expert witness testimony, ask EAG.

Techniques

Chromatography

Using an array of advanced separation techniques and innovative technology, we conduct highly precise analytical chromatography for various industries. Whether you want a closer…

Using an array of advanced separation techniques and innovative technology, we conduct highly precise analytical chromatography for various industries. Whether you want a closer look at the purity of your pharmaceutical or need to better understand an agrochemical’s components, EAG has the expertise to separate and evaluate any compound.

Mass Spectrometry

Need to evaluate the molecular structure of a compound or identify its origins? EAG knows how. With state-of-the-art tools, we can separate, vaporize and ionize the atoms and…

Need to evaluate the molecular structure of a compound or identify its origins? EAG knows how. With state-of-the-art tools, we can separate, vaporize and ionize the atoms and molecules in almost any pure or complex material to detect and obtain mass spectra of the components. We rely on decades of experience in mass spectrometry to provide our clients with precise analyses and the best detection limits.

Imaging

EAG is a world leader in high-resolution imaging down to the atomic level. We offer unmatched analytical know-how, generating extremely detailed surface and near surface images…

EAG is a world leader in high-resolution imaging down to the atomic level. We offer unmatched analytical know-how, generating extremely detailed surface and near surface images for various industries, from consumer electronics to nanotechnology. Using state-of-the-art equipment and innovative techniques, we conduct expert imaging to aid in failure analysis, dimensional analysis, process characterization, particle identification and more. If you want to investigate a material with angstrom scale resolution, you can count on EAG to get the job done quickly and precisely.

Spectroscopy

EAG offers a vast array of spectroscopic techniques to clients in various industries, from defense contractors to technology pioneers. We combine unparalleled expertise and…

EAG offers a vast array of spectroscopic techniques to clients in various industries, from defense contractors to technology pioneers. We combine unparalleled expertise and methodology with cutting-edge technology to analyze your organic, inorganic, metallic and composite materials for identification, compositional, structural and contaminant information. Whether you need expert spectroscopic analysis to improve your production process or to surmount a technical challenge, EAG is up to the task.

Physical/Chemical Characterization

Need to identify your unique material? Want to analyze the thermal properties of a sample, or measure the success of a process step? If it has to be done quickly and it has to be…

Need to identify your unique material? Want to analyze the thermal properties of a sample, or measure the success of a process step? If it has to be done quickly and it has to be done right, you can count on EAG. We offer a range of adaptable techniques and innovative methods to evaluate the physical and chemical characteristics of any compound. Our highly precise testing and analytical services will improve your production process, expedite R&D and help you conquer any technical challenge.

About

A Global Scientific Services Company

One of the most respected names in contract research and testing, EAG Laboratories is a global scientific services company operating at the intersection of science, technology and…

One of the most respected names in contract research and testing, EAG Laboratories is a global scientific services company operating at the intersection of science, technology and business. The scientists and engineers of EAG apply multi-disciplinary expertise, advanced analytical techniques and “we know how” resolve to answer complex questions that drive commerce around the world.

Our Customers

Science and technology transcend industry boundaries, and so does demand for EAG’s expertise. We partner with companies across a broad spectrum of high-tech, high-impact and…

Science and technology transcend industry boundaries, and so does demand for EAG’s expertise. We partner with companies across a broad spectrum of high-tech, high-impact and highly regulated industries. We help our customers innovate new and improved products, investigate manufacturing problems, perform advanced analyses to determine safety, efficacy and regulatory compliance, and protect their brands.

Our Company Culture

EAG’s corporate culture is firmly rooted in four guiding principles: “foster a growth mindset,” “find a better way,” “earn more loyal customers,” and “win…

EAG’s corporate culture is firmly rooted in four guiding principles: “foster a growth mindset,” “find a better way,” “earn more loyal customers,” and “win together.” Across all of our 20+ locations, you will find a true passion for science and the power of science to improve the world we live in. Hear what some of our ~1200 scientists, engineers and support personnel say about what it means to be part of EAG Laboratories.

Careers

EAG is growing, and we are always looking for talented, problem-solving oriented individuals to join our company. If you have a “we know how” spirit, we want to hear from you.…

EAG is growing, and we are always looking for talented, problem-solving oriented individuals to join our company. If you have a “we know how” spirit, we want to hear from you. Browse current openings now, and re-visit our careers page often.

How do you put science to work for you?

SETAC Europe 2017

Meet with EAG Laboratories at SETAC Europe 2017, the annual meeting of the Society of Environmental Toxicology and Chemistry, to be held May 7-11, 2017 in Brussels. We will be at Booths #5 and #7, and we are also presenting a technical poster. We look forward to meeting with our clients to discuss:

Contact us to schedule an appointment at SETAC Europe 2017!

EAG scientists will present during four technical programs:

Using a Database of Avian Reproductive Performance to Enhance Evaluation of Agrochemical Product Toxicity
Track and Session 1: Ecotoxicology and human toxicology (from molecules to organisms, from omics to in vivo).
Authors: Diana Temple, David Palmer, Kirsten Hammett, Tim Springer and Jared Ross (EAG Laboratories)

Avian reproduction studies with northern bobwhite (Colinus virginianus) and mallard (Anas platyrhnchos) have been conducted for nearly 40 years. The information collected from these gamebird species has been a primary part of the OECD and EPA regulatory program in evaluating agrichemical products and making environmental risk assessments. Data from these two species have been collected and maintained since the late 1970’s by Wildlife International (now operating as a division of EAG Laboratories). The databases compile values for reproductive parameters measured from birds used in each control group as part of each reproduction study conducted at the lab in Easton, Maryland, USA. The database compiles mean numbers of eggs laid, fertility of the eggs, normal development including viability and survival of the embryos, hatchability, offspring survival, egg shell thickness and weights of offspring and 14-day old survivors. Data collected in these records are becoming more critical in supporting evaluation of reproduction study results.

There is complexity in making meaningful decisions about the toxicity of agrochemical products. When ‘wild type’ birds are used we can expect inherent differences in performance and that occasional anomalies will occur. Rather than repeating multiple tests or increasing the number of birds tested, databases, such as this one, can help risk assessors and regulators make necessary judgements about the validity of differences observed in the range of reproductive parameters evaluated.  As the use and power of statistical programs such as CETIS® and TOXRAT® improve our ability to evaluate data and look at trends there is a need to balance these statistical evaluations with the integrity of the scientific processes observed in these toxicology tests. Moving forward a shared database system can be a valuable tool in improving interpretation of study results and evaluating mechanistic and population level effects.

Download the Application Note

The Importance of Weight of Evidence Considerations for Assessment of Potential Endocrine Activity: A Case Study for Carbaryl
Track and session 6: Environmental Policy, Risk Management and Risk Communication: Regulatory Best Practices for Assessment of Endocrine Active Substances
Authors: Duane Huggett (EAG Laboratories, Waterborne Environmental), Matt McCool, Lisa Ortego (Bayer CropScience) and Kevin Henry (NovaSource)

Carbaryl was included in the first list of chemicals to undergo Tier 1 screening in US EPA’s EDSP. Fish short-term reproduction assay (FSTRA) secondary male sex characteristics and gonadal histopathology data were interpreted as being suggestive of potential interaction with the androgen pathway in male fish. An EDSP Tier 2 Medaka Extended One-Generation Reproduction Test was suggested to be potentially useful based on these findings. The purpose of our analysis was to determine if potential endocrine responses in fish as seen in the FSTRA might be secondary to ChE inhibition.  An extensive review of the extant literature, standard guideline study reports, and relevant US EPA regulatory documents was conducted.

In male fish, there was an increased incidence of testicular degeneration as percentage of spermatogonia in the highest nominal treatment. There were no histopathological findings in females. There was a slight decrease in the median tubercle score (34 vs. 29 for controls vs. high dose, respectively). However, the remainder of the measurements related to endocrine modulation were negative. In addition, a fish full life cycle (FFLC) study was available in the fathead minnow. The highest nominal dose in this study resulted in marked reduction of F0 survival and F0 reproductive performance, with no reproductive effects seen at doses where impairments of growth and survival were observed.

Multiple studies have measured brain ChE levels in fish following exposure to carbaryl, as well as other carbamate pesticides. For example, two studies with rainbow trout reported statistically significant decreases in brain ChE levels at aqueous carbaryl concentrations ≤ 0.25 mg/L.

Based on previous studies, it can be concluded that carbaryl, at doses identified as levels demonstrating systemic toxicity in two fish reproductive studies, would be expected to inhibit ChE and is likely the primary mechanism driving reproductive and possible endocrine effects. In the FFLC study, concentrations that affected reproductive parameters also reduced survival, and the survival endpoint is thus protective of effects on reproduction, regardless of MoA. However, it can be concluded that the reproductive and endocrine findings in the FSTRA and the FFLC studies are secondary to ChE inhibition and systemic toxicity.

Advances in the Environmental Fate of Down-the-Drain Chemicals, including Pharmaceuticals
Platform session: Environmental Fate
Chairs: Duane Huggett and Ed Schaefer, EAG Laboratories

There is an increased interest in understanding the environmental risk of Down-the-Drain (DtD) chemicals, such as pharmaceuticals and personal care products.  Inherent in the environmental risk assessment (ERA) process is the conduct of environmental fate studies, such that a detailed understanding of the compartments of interest, rate kinetics and predicted environmental concentrations can be utilized within the ERA. With such interest in the DtD chemicals, it is not surprising that there has been a considerable amount of scientific advances to better predict the environmental fate of these types of chemicals. This proposed session will highlight the global advances in wastewater/watershed modeling and laboratory environmental fate studies, including the use of appropriate protocols and test conditions to more accurately reflect environmental conditions, leading to a more predictive paradigm for assessing the environmental fate of DtD chemicals.  The speakers will not only illustrate the advances in the field, but will draw upon the historical environmental fate methodologies conducted for these DtD chemicals and elucidate why some of the current tests (e.g. ready biodegradation test) may not be useful.   Session attendees will come away from this session with a detailed knowledge of the limitations of the current methodologies, as well as the new methodologies to overcome these limitations.

Future Challenges in Sediment Toxicity Testing for Environmental Risk Assessment
Poster Session
Chairs: Henry Krueger (EAG Laboratories) Daniel Faber, Theo Brock and Paul Sibley

Poster: Evaluating the Relative Sensitivity of Endpoints Generated During Midge LifeCycle Sediment Toxicity Tests for US Pesticide Registration, Author: Henry Krueger (EAG Laboratories)