Pharmaceutical & Biopharmaceutical Development Services
EAG brings unparalleled expertise to the development and commercialization of small molecule drugs, biopharmaceuticals, antibody-drug conjugates (ADCs), drug-device combination…
EAG brings unparalleled expertise to the development and commercialization of small molecule drugs, biopharmaceuticals, antibody-drug conjugates (ADCs), drug-device combination products and other therapies. From designing IND-enabling studies to delivering full CMC analytical and QC support, we join your R&D team as a true partner. EAG scientists take time to understand both your commercial goals and the unique characteristics of your compound. We provide expert guidance to balance regulatory expectations with expediency and cost, and approach technical challenges with flexibility and resolve.
When it comes to understanding the physical structure, chemical properties and composition of materials, no scientific services company offers the breadth of experience, diversity…
When it comes to understanding the physical structure, chemical properties and composition of materials, no scientific services company offers the breadth of experience, diversity of analytical techniques of technical ingenuity of EAG. From polymers to composites, thin films to superalloys—we know how to leverage materials sciences to gain a competitive edge. At EAG, we don’t just perform testing, we drive commercial success—through thoughtfully designed investigations, technically superior analyses and expert interpretation of data.
Having helped develop the test methods that shape current regulatory guidelines, EAG chemists, biologists and toxicologists have evaluated the environmental impact of thousands of…
Having helped develop the test methods that shape current regulatory guidelines, EAG chemists, biologists and toxicologists have evaluated the environmental impact of thousands of active ingredients and formulations—from pesticides and pharmaceuticals to industrial chemicals and consumer products. Whether you are exploring “what if” scenarios, registering a new active ingredient or formulation, responding to a data call-in or seeking to understand the latest guidance, turn to EAG for technical excellence, sound advice, GLP-compliant study execution and expert interpretation.
Whether connecting the internet of things, guiding surgical lasers or powering the latest smart phone, integrated circuits and microelectronics touch nearly every aspect of human…
Whether connecting the internet of things, guiding surgical lasers or powering the latest smart phone, integrated circuits and microelectronics touch nearly every aspect of human life. In the world of technology, innovation and continuous improvement are imperatives—and being able to quickly and reliably test, debug, diagnose failures and take corrective action can make the difference between a doomed product launch and building a successful global brand. EAG offers you the world’s largest and most diverse collection of specialized analytical instrumentation, capacity to perform a variety of microelectronic tests in parallel, and the multi-disciplinary expertise required to draw true insight from data.
No contract service provider has more experience performing custom synthesis and producing isotopically labeled compounds to support product development in life science, chemical…
No contract service provider has more experience performing custom synthesis and producing isotopically labeled compounds to support product development in life science, chemical and related industries than we do. From 14C and 3H radiolabeled clinical trial materials synthesized under cGMP, to stable-labeled active ingredients for metabolism and environmental fate/effects testing, turn to EAG. We have extensive experience with multi-step and other complex synthesis projects, and our comprehensive, in-house analytical services ensure quick turnaround of purity and structural confirmation.
EAG combines biotechnology and protein characterization expertise with more than 50 years' experience analyzing chemical compounds in plant and environmental matrices to address…
EAG combines biotechnology and protein characterization expertise with more than 50 years’ experience analyzing chemical compounds in plant and environmental matrices to address the growing needs of the biotechnology crop industry. We offer a wide range of techniques required to fully characterize the event insertion and expressed proteins, as well as the various studies required to confirm the food, feed and environmental safety of products that represent the trait. From early-stage protein confirmation to GLP-compliant EDSP and allergenicity testing, we help you make faster, more informed development decisions and comply with evolving global regulations of genetically engineered crops.
When you need solid science and investigative engineering to address product failures, inform legal strategy, protect intellectual property or address product liability disputes,…
When you need solid science and investigative engineering to address product failures, inform legal strategy, protect intellectual property or address product liability disputes, turn to EAG. We’ve provided technical consulting, analysis and expert testimony for hundreds of cases involving the aerospace, transportation, medical device, electronics, industrial and consumer product industries. Our team of experts understands the legal process and your need for responsiveness, effective communication, scientifically defensible opinion and confidentiality. From professional consulting to data review to trial preparation and expert witness testimony, ask EAG.
Using an array of advanced separation techniques and innovative technology, we conduct highly precise analytical chromatography for various industries. Whether you want a closer…
Using an array of advanced separation techniques and innovative technology, we conduct highly precise analytical chromatography for various industries. Whether you want a closer look at the purity of your pharmaceutical or need to better understand an agrochemical’s components, EAG has the expertise to separate and evaluate any compound.
Need to evaluate the molecular structure of a compound or identify its origins? EAG knows how. With state-of-the-art tools, we can separate, vaporize and ionize the atoms and…
Need to evaluate the molecular structure of a compound or identify its origins? EAG knows how. With state-of-the-art tools, we can separate, vaporize and ionize the atoms and molecules in almost any pure or complex material to detect and obtain mass spectra of the components. We rely on decades of experience in mass spectrometry to provide our clients with precise analyses and the best detection limits.
EAG is a world leader in high-resolution imaging down to the atomic level. We offer unmatched analytical know-how, generating extremely detailed surface and near surface images…
EAG is a world leader in high-resolution imaging down to the atomic level. We offer unmatched analytical know-how, generating extremely detailed surface and near surface images for various industries, from consumer electronics to nanotechnology. Using state-of-the-art equipment and innovative techniques, we conduct expert imaging to aid in failure analysis, dimensional analysis, process characterization, particle identification and more. If you want to investigate a material with angstrom scale resolution, you can count on EAG to get the job done quickly and precisely.
EAG offers a vast array of spectroscopic techniques to clients in various industries, from defense contractors to technology pioneers. We combine unparalleled expertise and…
EAG offers a vast array of spectroscopic techniques to clients in various industries, from defense contractors to technology pioneers. We combine unparalleled expertise and methodology with cutting-edge technology to analyze your organic, inorganic, metallic and composite materials for identification, compositional, structural and contaminant information. Whether you need expert spectroscopic analysis to improve your production process or to surmount a technical challenge, EAG is up to the task.
Need to identify your unique material? Want to analyze the thermal properties of a sample, or measure the success of a process step? If it has to be done quickly and it has to be…
Need to identify your unique material? Want to analyze the thermal properties of a sample, or measure the success of a process step? If it has to be done quickly and it has to be done right, you can count on EAG. We offer a range of adaptable techniques and innovative methods to evaluate the physical and chemical characteristics of any compound. Our highly precise testing and analytical services will improve your production process, expedite R&D and help you conquer any technical challenge.
One of the most respected names in contract research and testing, EAG Laboratories is a global scientific services company operating at the intersection of science, technology and…
One of the most respected names in contract research and testing, EAG Laboratories is a global scientific services company operating at the intersection of science, technology and business. The scientists and engineers of EAG apply multi-disciplinary expertise, advanced analytical techniques and “we know how” resolve to answer complex questions that drive commerce around the world.
Science and technology transcend industry boundaries, and so does demand for EAG’s expertise. We partner with companies across a broad spectrum of high-tech, high-impact and…
Science and technology transcend industry boundaries, and so does demand for EAG’s expertise. We partner with companies across a broad spectrum of high-tech, high-impact and highly regulated industries. We help our customers innovate new and improved products, investigate manufacturing problems, perform advanced analyses to determine safety, efficacy and regulatory compliance, and protect their brands.
EAG’s corporate culture is firmly rooted in four guiding principles: “foster a growth mindset,” “find a better way,” “earn more loyal customers,” and “win…
EAG’s corporate culture is firmly rooted in four guiding principles: “foster a growth mindset,” “find a better way,” “earn more loyal customers,” and “win together.” Across all of our 20+ locations, you will find a true passion for science and the power of science to improve the world we live in. Hear what some of our ~1200 scientists, engineers and support personnel say about what it means to be part of EAG Laboratories.
EAG is growing, and we are always looking for talented, problem-solving oriented individuals to join our company. If you have a “we know how” spirit, we want to hear from you.…
EAG is growing, and we are always looking for talented, problem-solving oriented individuals to join our company. If you have a “we know how” spirit, we want to hear from you. Browse current openings now, and re-visit our careers page often.
Optimizing 2-D Electron Density in pHEMTs Using Secondary Ion Mass Spectrometry
In a heterostructure FET (HFET) a heterojunction interface between an n-AlGaAs donor layer and an undoped InGaAs layer leads to a change in the conduction and valence bands at the interface that creates a sharp potential well in which donor electrons can reside under a forward gate bias condition. The depth of this well is determined by the exact composition of the two hetero materials on either side of the interface. Injection of electrons from the AlGaAs layer into the InGaAs layer results in electrons being separated from the Si donor ions and confined in a thin layer in the InGaAs near the interface. This thin plane of electrons is highly mobile and forms a two dimensional electron gas (2DEG) layer for transconductance of current between the source and drain of the device.
Typically, to aid in separating the electrons from the donor ions (which improves electron mobility due to decreased scattering) the grower typically incorporates a very thin AlGaAs or GaAs “spacer” layer between the Si donor atoms (present as a delta doping spike in the AlGaAs) and the InGaAs channel region. PHEMT growers typically target certain electron mobility and charge density, which can be accomplished, respectively by spacer layer thickness and doping concentration.
One must be careful, however, because too great a spacer layer thickness will decrease the number of electrons able to tunnel from their donor atoms across the heterostructure interface and into the InGaAs channel thus reducing the charge density in the 2DEG. A thinner spacer layer will not sufficiently separate the electrons from the donor atoms and increased scattering of the electrons off these donor atoms will result in decreased electron mobility. However, an increase in charge density would result.
Likewise, the grower must be careful in growing the Si deltadoping spikes. Too low a doping level will result in decrease electron density in the 2DEG layer, while too high a doping level will result in increased electron scattering from the Si donor atoms which, as mentioned above, results in decreased electron mobility. So the grower has a “balancing act” to perform in fabricating these structures. See figure 1.
Figure 1. “Balancing Act” that the pHEMT grower must perform
Adding to the complication is that reaching the targeted spacer thickness can be difficult because the methods typically used to fabricate pHEMTs can be difficult to control. Because the spacer layer (25 – 40 Å) is so thin, brief growth durations are required, and what is more, they occur between critical actuation of shutters and valves that are pausing the growth of the matrix elements as well as turning on and off the dopant. The subsequent flux decays are dependent on cell conditions such as geometry, temperature, pause times, carrier gas flow, etc which are all difficult to characterize.
Ultimately, the PCOR-SIMSSM profile can provide the information needed by the grower/designer regarding doping levels and spacer layer thicknesses that are actually achieved in a growth run. This factually helps the grower to know where he exactly stands in reference to the targeted values.
Crucial to the success at using SIMS for this application is its ability to determine accurately:
III-V material compositions (for energy band optimization)
Spacer layer thickness
The vast number of combinations of Group III and Group V materials that are commonly used in modern III-V devices creates severe problems for the SIMS in achieving these requirements. Large numbers of standards needed to achieve quantitative accuracy, and many supportive techniques must be brought to bear to confirm the SIMS results. The efforts of the EAG for this very challenging area of materials analysis are met by Point-by- Point-Corrected SIMS (PCOR-SIMSSM).
PCOR-SIMSSM accurately measures the areal density of the Si doping spikes and accurately determines layer thicknesses by taking into account the change in Si SIMS sensitivity and sputtering rate with AlGaAs and InGaAs composition.
Figure 2. Routine PCOR-SIMSSMprofile of the channel region of an AlGaAs/InGaAs pHEMT device.
Figure 2 demonstrates the usefulness of PCOR-SIMSSM for optimizing the channel region of a pHEMT device in which the 2DEG resides. This particular device a double-heterostructure (DH) FET where the conducting channel (InGaAs in this example) is bounded on both sides by AlGaAs confinement layers with doping being supplied from two Si planar doping layers, one on either side of the channel. The effect of the confinement is to increase the effective carrier velocity in the channel. The complication is then to manage simultaneously the charge transfer from both sides of the channel. In fact, the effective contribution to the charge from each side is a function of the spacer and the Si dose. The ultimate contribution ratio is not necessarily the same as the nominal atomic concentration of dopant (Si). In addition, the behavior is not linear over the generally used range of doping doses. The matter gets further complicated when an asymmetric configuration is used; namely when the spacer thicknesses are not the same. The depth resolution of the analysis reveals the spacer layers, as well, even though they are as thin as 35Å. The differences in sputter rates between AlGaAs, InGaAs and GaAs are corrected at each point. This is necessary for pHEMT structures for accurate evaluation of the spacer layer, which corresponds to the AlGaAs layer thickness between the Si spiked layer and the start of the InGaAs layer (i.e. half rise in In profile). By utilizing the Si profiles, the AlGaAs layers ranging from a few tens to few hundreds of Angstroms can be accurately segmented between the upper AlGaAs layer and the lower spacer layer. Other analytical techniques may identify the total AlGaAs layer thickness, but SIMS is unique in being able to unambiguously divide this layer into its two halves.
Figure 3. Relationship between spacer layer thickness (as measured by PCOR-SIMSSM) and electron mobility.
Figure 3 demonstrates the ability of PCOR-SIMSSM to measure the spacer layer thickness with sufficient accuracy to establish the quantitative relationship between spacer layer thickness and electron mobility. As stated in the introduction, mobility depends on the spacer layer thickness (as well as other things). We wish to show that, other structure variables being unchanged, SIMS can measure a change in spacer layer thickness that would be consistent with a measured change in mobility. The physical separation between Si donor ion and electron prevents unwanted Coulombic scattering resulting in high e-velocities in the active layer (and thus higher electron mobility. Examples of SIMS depth profiles from two of these samples are shown in Fig. 4.
Figure 4. PCOR-SIMSSMprofiles of the active region of two of the samples from the Spacer Layer study shown in Fig. 3. The measured thicknesses of the spacer layers of the two structures are shown in the figure.
A similar relationship can been seen in figure 5 between the amount of electron charge density in the pHEMT active layer (InGaAs) and the areal density of Si donors in the Si delta-doped layer. During application of a forward bias at the gate electrode, the amount of electrons that can charge transfer from the donor atoms into the (InGaAs) active layer is dependent on the amount of Si donor atoms present in the Si delta-doped layer.
In addition to these examples of using PCOR-SIMSSM for process development, PCOR-SIMSSM can also be used for failure analysis of pHEMTs. Figure 6 shows PCOR-SIMSSM profiles in the active region of a “good” and a “poor” pHEMT. For these two PHEMT structures, note the difference in peak Si concentration in the top Si delta-doped layer. The increased apparent diffusion of the top Si spike towards the surface can be the result of either too high a growth temperature or imperfect switching off the dopant source for the upper delta doping (but most likely both). Also in Fig. 6, note the diffusion of the Si doping spike away from the InGaAs channel region. This reduces the number of donor atoms that reside close enough to the conduction band offset (AlGaAs/InGaAs interface) to allow a sufficient number of electrons to tunnel into the channel region resulting in degraded device performance as it will require more atomic Si to achieve the needed charge but this is undesirable because of increased electron scattering. It is also possible that a broader Si delta distribution could lower the breakdown voltage.
Figure 5. Relationship between total Si areal density in deltadoped spikes (as measured by PCOR-SIMSSM) and active layer charge density for a thin spacer (red curve) and for a thick spacer (green curve).
Fig. 6. Routine SIMS profiles of the Group III elemental composition and the Si doping spikes for good and bad HEMT devices.
In conclusion, we have shown how PCOR-SIMSSM can be used by the grower of III-V high-speed transistor structures by helping to optimize the “balancing act” tradeoff of structural features that determine electron mobility and electron change density in the channel region, both or which affect device performance. Despite the accessibility of some powerful techniques to the grower, the assessment of the device in the vicinity of the channel region, namely the interfacial region, is better and most factually assessed by SIMS. This enables the grower to determine exactly what is happening to cause the observables by other testing means.