Industries
Services

Pharmaceutical & Biopharmaceutical Development Services

EAG brings unparalleled expertise to the development and commercialization of small molecule drugs, biopharmaceuticals, antibody-drug conjugates (ADCs), drug-device combination…

EAG brings unparalleled expertise to the development and commercialization of small molecule drugs, biopharmaceuticals, antibody-drug conjugates (ADCs), drug-device combination products and other therapies. From designing IND-enabling studies to delivering full CMC analytical and QC support, we join your R&D team as a true partner. EAG scientists take time to understand both your commercial goals and the unique characteristics of your compound. We provide expert guidance to balance regulatory expectations with expediency and cost, and approach technical challenges with flexibility and resolve.

Materials Testing & Analysis

When it comes to understanding the physical structure, chemical properties and composition of materials, no scientific services company offers the breadth of experience, diversity…

When it comes to understanding the physical structure, chemical properties and composition of materials, no scientific services company offers the breadth of experience, diversity of analytical techniques of technical ingenuity of EAG. From polymers to composites, thin films to superalloys—we know how to leverage materials sciences to gain a competitive edge. At EAG, we don’t just perform testing, we drive commercial success—through thoughtfully designed investigations, technically superior analyses and expert interpretation of data.

Environmental Testing & Regulatory Compliance

Having helped develop the test methods that shape current regulatory guidelines, EAG chemists, biologists and toxicologists have evaluated the environmental impact of thousands of…

Having helped develop the test methods that shape current regulatory guidelines, EAG chemists, biologists and toxicologists have evaluated the environmental impact of thousands of active ingredients and formulations—from pesticides and pharmaceuticals to industrial chemicals and consumer products. Whether you are exploring “what if” scenarios, registering a new active ingredient or formulation, responding to a data call-in or seeking to understand the latest guidance, turn to EAG for technical excellence, sound advice, GLP-compliant study execution and expert interpretation.

Microelectronics Test & Engineering

Whether connecting the internet of things, guiding surgical lasers or powering the latest smart phone, integrated circuits and microelectronics touch nearly every aspect of human…

Whether connecting the internet of things, guiding surgical lasers or powering the latest smart phone, integrated circuits and microelectronics touch nearly every aspect of human life. In the world of technology, innovation and continuous improvement are imperatives—and being able to quickly and reliably test, debug, diagnose failures and take corrective action can make the difference between a doomed product launch and building a successful global brand. EAG offers you the world’s largest and most diverse collection of specialized analytical instrumentation, capacity to perform a variety of microelectronic tests in parallel, and the multi-disciplinary expertise required to draw true insight from data.

Custom Synthesis & Radiolabeling

No contract service provider has more experience performing custom synthesis and producing isotopically labeled compounds to support product development in life science, chemical…

No contract service provider has more experience performing custom synthesis and producing isotopically labeled compounds to support product development in life science, chemical and related industries than we do. From 14C and 3H radiolabeled clinical trial materials synthesized under cGMP, to stable-labeled active ingredients for metabolism and environmental fate/effects testing, turn to EAG. We have extensive experience with multi-step and other complex synthesis projects, and our comprehensive, in-house analytical services ensure quick turnaround of purity and structural confirmation.

Crop Biotechnology & Development

EAG combines biotechnology and protein characterization expertise with more than 50 years' experience analyzing chemical compounds in plant and environmental matrices to address…

EAG combines biotechnology and protein characterization expertise with more than 50 years’ experience analyzing chemical compounds in plant and environmental matrices to address the growing needs of the biotechnology crop industry. We offer a wide range of techniques required to fully characterize the event insertion and expressed proteins, as well as the various studies required to confirm the food, feed and environmental safety of products that represent the trait. From early-stage protein confirmation to GLP-compliant EDSP and allergenicity testing, we help you make faster, more informed development decisions and comply with evolving global regulations of genetically engineered crops.

Litigation Support & Expert Testimony

When you need solid science and investigative engineering to address product failures, inform legal strategy, protect intellectual property or address product liability disputes,…

When you need solid science and investigative engineering to address product failures, inform legal strategy, protect intellectual property or address product liability disputes, turn to EAG. We’ve provided technical consulting, analysis and expert testimony for hundreds of cases involving the aerospace, transportation, medical device, electronics, industrial and consumer product industries. Our team of experts understands the legal process and your need for responsiveness, effective communication, scientifically defensible opinion and confidentiality. From professional consulting to data review to trial preparation and expert witness testimony, ask EAG.

Techniques

Chromatography

Using an array of advanced separation techniques and innovative technology, we conduct highly precise analytical chromatography for various industries. Whether you want a closer…

Using an array of advanced separation techniques and innovative technology, we conduct highly precise analytical chromatography for various industries. Whether you want a closer look at the purity of your pharmaceutical or need to better understand an agrochemical’s components, EAG has the expertise to separate and evaluate any compound.

Mass Spectrometry

Need to evaluate the molecular structure of a compound or identify its origins? EAG knows how. With state-of-the-art tools, we can separate, vaporize and ionize the atoms and…

Need to evaluate the molecular structure of a compound or identify its origins? EAG knows how. With state-of-the-art tools, we can separate, vaporize and ionize the atoms and molecules in almost any pure or complex material to detect and obtain mass spectra of the components. We rely on decades of experience in mass spectrometry to provide our clients with precise analyses and the best detection limits.

Imaging

EAG is a world leader in high-resolution imaging down to the atomic level. We offer unmatched analytical know-how, generating extremely detailed surface and near surface images…

EAG is a world leader in high-resolution imaging down to the atomic level. We offer unmatched analytical know-how, generating extremely detailed surface and near surface images for various industries, from consumer electronics to nanotechnology. Using state-of-the-art equipment and innovative techniques, we conduct expert imaging to aid in failure analysis, dimensional analysis, process characterization, particle identification and more. If you want to investigate a material with angstrom scale resolution, you can count on EAG to get the job done quickly and precisely.

Spectroscopy

EAG offers a vast array of spectroscopic techniques to clients in various industries, from defense contractors to technology pioneers. We combine unparalleled expertise and…

EAG offers a vast array of spectroscopic techniques to clients in various industries, from defense contractors to technology pioneers. We combine unparalleled expertise and methodology with cutting-edge technology to analyze your organic, inorganic, metallic and composite materials for identification, compositional, structural and contaminant information. Whether you need expert spectroscopic analysis to improve your production process or to surmount a technical challenge, EAG is up to the task.

Physical/Chemical Characterization

Need to identify your unique material? Want to analyze the thermal properties of a sample, or measure the success of a process step? If it has to be done quickly and it has to be…

Need to identify your unique material? Want to analyze the thermal properties of a sample, or measure the success of a process step? If it has to be done quickly and it has to be done right, you can count on EAG. We offer a range of adaptable techniques and innovative methods to evaluate the physical and chemical characteristics of any compound. Our highly precise testing and analytical services will improve your production process, expedite R&D and help you conquer any technical challenge.

About

A Global Scientific Services Company

One of the most respected names in contract research and testing, EAG Laboratories is a global scientific services company operating at the intersection of science, technology and…

One of the most respected names in contract research and testing, EAG Laboratories is a global scientific services company operating at the intersection of science, technology and business. The scientists and engineers of EAG apply multi-disciplinary expertise, advanced analytical techniques and “we know how” resolve to answer complex questions that drive commerce around the world.

Our Customers

Science and technology transcend industry boundaries, and so does demand for EAG’s expertise. We partner with companies across a broad spectrum of high-tech, high-impact and…

Science and technology transcend industry boundaries, and so does demand for EAG’s expertise. We partner with companies across a broad spectrum of high-tech, high-impact and highly regulated industries. We help our customers innovate new and improved products, investigate manufacturing problems, perform advanced analyses to determine safety, efficacy and regulatory compliance, and protect their brands.

Our Company Culture

EAG’s corporate culture is firmly rooted in four guiding principles: “foster a growth mindset,” “find a better way,” “earn more loyal customers,” and “win…

EAG’s corporate culture is firmly rooted in four guiding principles: “foster a growth mindset,” “find a better way,” “earn more loyal customers,” and “win together.” Across all of our 20+ locations, you will find a true passion for science and the power of science to improve the world we live in. Hear what some of our ~1200 scientists, engineers and support personnel say about what it means to be part of EAG Laboratories.

Careers

EAG is growing, and we are always looking for talented, problem-solving oriented individuals to join our company. If you have a “we know how” spirit, we want to hear from you.…

EAG is growing, and we are always looking for talented, problem-solving oriented individuals to join our company. If you have a “we know how” spirit, we want to hear from you. Browse current openings now, and re-visit our careers page often.

How do you make better development decisions faster?

'The Science of Drug Development' Webinar Series

Bringing together some of the brightest minds in both the public and private sectors, the ‘Science of Drug Development’ webinar series is a joint effort between EAG Laboratories and the University of Wisconsin. A public/private educational venture, the series aims to help organizations eliminate obstacles that stand in the way of bringing the next generation of pharmaceuticals to market.

Each month, the ‘Science of Drug Development’ webinar series brings leading experts in pharmaceutical research right to your computer.

Analytical Method Transfers: Practice and Pitfalls
Recorded: Thursday, May 18, 2017

Recorded: Thursday, May 18, 2017

Presenter: Wayland Rushing

When planning your development timeline, the transfer of analytical methods is rarely more than a blip on your radar.  But when a method doesn’t perform as expected, it can take precious days of investigative work to find the problem, and even more to correct it. Learn about common pitfalls that cause method transfer failures, how to decide what type of method transfer makes sense for your study, and how to implement a fail-safe communication plan that will help put your outsourcing relationship on the right course.


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Eccentricity of Method Validation Related
to Guidance and Best Practices

Recorded: Thursday, June 15, 2017

Recorded: Thursday, June 15, 2017

Presenter: Harley Wilcox

Today there exists a fairly clear understanding of the intent of the suitability of analytical methods for pharmaceuticals.  ICH, FDA guidance, literature, and USP-published information provide detail specifically for chromatographic methodology and validation and requirements for market approval.  Less information exists for method suitability for early phase development and non-chromatographic methods. Stress testing, method robustness and reproducibility are often performed for registration validation but play an important role in early method development but are not exclusive of validation. How to handle early and late stage suitability and interpret possible inconsistencies in published information will be discussed. This will include case studies, and provide parameters of registration validations as well as applications to drug development stages.


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Synthesis/Radiolabeling: Ten Things You Should
Know Before Contracting Custom Synthesis

Recorded: Thursday, July 13, 2017

Recorded: Thursday, July 13, 2017

Presenter: Jim Schmidt

Companies often need to arrange for the synthesis of test substances to support research and development efforts. Synthesized test materials range from active ingredients, intermediates, fine chemicals and reference standards to impurities and metabolites. Depending on the type and depth of data required, custom synthesized materials may need to be radiolabeled, stable-labeled or non-radiolabeled; and depending on the type of study, a GxP manufacturing environment may be necessary. There are many important decisions to consider before proceeding with a contract for custom synthesis.  This presentation addresses communication, regulatory requirements, strategic use of isotopes, position of radiolabel, timing; scalability; re-purification/characterization; metabolite and impurity reference standards; analytical support; intellectual property and more.


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ADC Development: Keys to Rapid IND Submission & Approval
Recorded: August 10, 2017

Recorded:  Thursday, August 10, 2017

Presenter: Glenn Petrie, Ph.D.

Antibody Drug Conjugates (ADCs) are a growing segment of the biopharmaceutical pipeline with currently dozens of ADCs in clinical trials and an estimated 150 in pre-clinical development. ADCs consist of a payload (toxin) covalently linked to a targeting sub-unit (monoclonal antibody). The vast majority of ADCs are utilized for the treatment of solid and hematological cancers. The antibody sub-unit binds to the cancer cell surface and the ADC is internalized to the cell cytoplasm.  The endosome fuses with lysosomes resulting in cleavage of the linker, release of the free cytotoxin and cell death.


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The Critical Role of CMC in Your Biopharmaceutical
IND Submission – Optimizing the CMC Process

Recorded: September 7, 2017

Recorded: September 7, 2017

Presenter: Glenn Petrie

Drug development programs are rightfully targeted toward initiation of clinical trials. Based on this goal, emphasis is typically placed upon toxicological and pharmacological studies, sometimes at the expense of Chemistry, Manufacturing and Control (CMC). CMC is critical to IND approval and requires careful planning in order to meet all FDA requirements. This discussion will focus on the primary CMC requirements for a biopharmaceutical IND submission. The risk/reward criteria for determining the level and degree of method validation, reference standard characterization and formulation will be discussed in terms of streamlining the entire development process. In addition, possible pitfalls in the development process will be identified and addressed.


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Stereo-Selectivity in Drug Metabolism
Recorded: October 5, 2017

Recorded: Thursday, October 5, 2017

Presenter: Jim Schmidt

There are few aspects of drug metabolism and metabolite profiling more essential – and more interesting – than exploring stereo-selective metabolism. For the better part of a century, the consideration of chirality in drug metabolism was limited to academic study and/or to natural products, owing in no small part to the limits of separations chemistry. However, chirality has been earning ever-greater importance in drug discovery and development, such that most of the new molecular entities reaching the market in the first decades of the 21st century are single enantiomers, rather than the racemic mixtures (or achiral drugs) that dominated the latter half of the 20th century.

Stereo-selective metabolism has important impacts on scientific aspects such as pharmacokinetics, pharmacodynamics, drug safety, and bio-analytical chemistry; but also on regulatory, intellectual property, business and product development, and other important considerations. In this webinar you will view examples of typical stereo-selective metabolism reactions, potential drug-drug interactions, and bio-analytical chemistry approaches. A case study of stereo-selective metabolism and metabolite profiling will also be presented, with important questions to consider.


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The Challenge of Detecting Mutagenic Impurities
Recorded: December 7, 2017

Recorded: Thursday, December 7, 2017

Presenter: Harley Wilcox

Current guidelines including ICH M7 provide an overview of assessing and evaluating limits of impurities in pharmaceuticals that are suspected or classified as mutagenic impurities. These impurities may be associated with known added agents, environment, or degradation products from pharmaceutical compositions.  Proposed limits for genotoxic impurities reside well below common impurities discussed in ICH Q3A guidance and require analytical techniques capable of detecting and measuring ppm to ppb levels. This webinar provides an overview of analytical technologies for detecting mutagenic impurities.


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Leachables Stability Studies
Live Webinar: February 13, 2018

Live Webinar: Tuesday, February 13,
2018 11:00 AM – 12:00 PM CST

Presenter: Wayland Rushing

Leachables are impurities which originate from contact surfaces (typically the final container/closure system). Performing leachable stability studies can be challenging and is generally less understood than for typical drug product related impurities. ICH stability requirements are not directly applicable to leachables. This presentation will cover: what are leachables and where do they come from, what are the similarities and difference to drug product related impurities, what are the method and stability requirements.


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Coming soon:
Don't miss these additional upcoming webinars

Other webinars coming soon, including:

  • Product Chemistry: Characterization of Polymer Extractability and Hydrolysis – a Guide to Performing OECD 120 and OECD 111 Studies with Polymers

    Presenter: Jim Schmidt

  • E&L for Complex or Non-Standard Formulations/Delivery Systems

    Presenter: Wayland Rushing

  • Leachables Stability Studies

    Presenter: Wayland Rushing

  • cGMP Radiosynthesis for Early Phase Clinical Trials: A Unique Challenge and Development of a Standard Process

    Presenter: Wayland Rushing