Industries
Services

Pharmaceutical & Biopharmaceutical Development Services

EAG brings unparalleled expertise to the development and commercialization of small molecule drugs, biopharmaceuticals, antibody-drug conjugates (ADCs), drug-device combination…

EAG brings unparalleled expertise to the development and commercialization of small molecule drugs, biopharmaceuticals, antibody-drug conjugates (ADCs), drug-device combination products and other therapies. From designing IND-enabling studies to delivering full CMC analytical and QC support, we join your R&D team as a true partner. EAG scientists take time to understand both your commercial goals and the unique characteristics of your compound. We provide expert guidance to balance regulatory expectations with expediency and cost, and approach technical challenges with flexibility and resolve.

Materials Testing & Analysis

When it comes to understanding the physical structure, chemical properties and composition of materials, no scientific services company offers the breadth of experience, diversity…

When it comes to understanding the physical structure, chemical properties and composition of materials, no scientific services company offers the breadth of experience, diversity of analytical techniques of technical ingenuity of EAG. From polymers to composites, thin films to superalloys—we know how to leverage materials sciences to gain a competitive edge. At EAG, we don’t just perform testing, we drive commercial success—through thoughtfully designed investigations, technically superior analyses and expert interpretation of data.

Environmental Testing & Regulatory Compliance

Having helped develop the test methods that shape current regulatory guidelines, EAG chemists, biologists and toxicologists have evaluated the environmental impact of thousands of…

Having helped develop the test methods that shape current regulatory guidelines, EAG chemists, biologists and toxicologists have evaluated the environmental impact of thousands of active ingredients and formulations—from pesticides and pharmaceuticals to industrial chemicals and consumer products. Whether you are exploring “what if” scenarios, registering a new active ingredient or formulation, responding to a data call-in or seeking to understand the latest guidance, turn to EAG for technical excellence, sound advice, GLP-compliant study execution and expert interpretation.

Microelectronics Test & Engineering

Whether connecting the internet of things, guiding surgical lasers or powering the latest smart phone, integrated circuits and microelectronics touch nearly every aspect of human…

Whether connecting the internet of things, guiding surgical lasers or powering the latest smart phone, integrated circuits and microelectronics touch nearly every aspect of human life. In the world of technology, innovation and continuous improvement are imperatives—and being able to quickly and reliably test, debug, diagnose failures and take corrective action can make the difference between a doomed product launch and building a successful global brand. EAG offers you the world’s largest and most diverse collection of specialized analytical instrumentation, capacity to perform a variety of microelectronic tests in parallel, and the multi-disciplinary expertise required to draw true insight from data.

Custom Synthesis & Radiolabeling

No contract service provider has more experience performing custom synthesis and producing isotopically labeled compounds to support product development in life science, chemical…

No contract service provider has more experience performing custom synthesis and producing isotopically labeled compounds to support product development in life science, chemical and related industries than we do. From 14C and 3H radiolabeled clinical trial materials synthesized under cGMP, to stable-labeled active ingredients for metabolism and environmental fate/effects testing, turn to EAG. We have extensive experience with multi-step and other complex synthesis projects, and our comprehensive, in-house analytical services ensure quick turnaround of purity and structural confirmation.

Crop Biotechnology & Development

EAG combines biotechnology and protein characterization expertise with more than 50 years' experience analyzing chemical compounds in plant and environmental matrices to address…

EAG combines biotechnology and protein characterization expertise with more than 50 years’ experience analyzing chemical compounds in plant and environmental matrices to address the growing needs of the biotechnology crop industry. We offer a wide range of techniques required to fully characterize the event insertion and expressed proteins, as well as the various studies required to confirm the food, feed and environmental safety of products that represent the trait. From early-stage protein confirmation to GLP-compliant EDSP and allergenicity testing, we help you make faster, more informed development decisions and comply with evolving global regulations of genetically engineered crops.

Litigation Support & Expert Testimony

When you need solid science and investigative engineering to address product failures, inform legal strategy, protect intellectual property or address product liability disputes,…

When you need solid science and investigative engineering to address product failures, inform legal strategy, protect intellectual property or address product liability disputes, turn to EAG. We’ve provided technical consulting, analysis and expert testimony for hundreds of cases involving the aerospace, transportation, medical device, electronics, industrial and consumer product industries. Our team of experts understands the legal process and your need for responsiveness, effective communication, scientifically defensible opinion and confidentiality. From professional consulting to data review to trial preparation and expert witness testimony, ask EAG.

Techniques

Chromatography

Using an array of advanced separation techniques and innovative technology, we conduct highly precise analytical chromatography for various industries. Whether you want a closer…

Using an array of advanced separation techniques and innovative technology, we conduct highly precise analytical chromatography for various industries. Whether you want a closer look at the purity of your pharmaceutical or need to better understand an agrochemical’s components, EAG has the expertise to separate and evaluate any compound.

Mass Spectrometry

Need to evaluate the molecular structure of a compound or identify its origins? EAG knows how. With state-of-the-art tools, we can separate, vaporize and ionize the atoms and…

Need to evaluate the molecular structure of a compound or identify its origins? EAG knows how. With state-of-the-art tools, we can separate, vaporize and ionize the atoms and molecules in almost any pure or complex material to detect and obtain mass spectra of the components. We rely on decades of experience in mass spectrometry to provide our clients with precise analyses and the best detection limits.

Imaging

EAG is a world leader in high-resolution imaging down to the atomic level. We offer unmatched analytical know-how, generating extremely detailed surface and near surface images…

EAG is a world leader in high-resolution imaging down to the atomic level. We offer unmatched analytical know-how, generating extremely detailed surface and near surface images for various industries, from consumer electronics to nanotechnology. Using state-of-the-art equipment and innovative techniques, we conduct expert imaging to aid in failure analysis, dimensional analysis, process characterization, particle identification and more. If you want to investigate a material with angstrom scale resolution, you can count on EAG to get the job done quickly and precisely.

Spectroscopy

EAG offers a vast array of spectroscopic techniques to clients in various industries, from defense contractors to technology pioneers. We combine unparalleled expertise and…

EAG offers a vast array of spectroscopic techniques to clients in various industries, from defense contractors to technology pioneers. We combine unparalleled expertise and methodology with cutting-edge technology to analyze your organic, inorganic, metallic and composite materials for identification, compositional, structural and contaminant information. Whether you need expert spectroscopic analysis to improve your production process or to surmount a technical challenge, EAG is up to the task.

Physical/Chemical Characterization

Need to identify your unique material? Want to analyze the thermal properties of a sample, or measure the success of a process step? If it has to be done quickly and it has to be…

Need to identify your unique material? Want to analyze the thermal properties of a sample, or measure the success of a process step? If it has to be done quickly and it has to be done right, you can count on EAG. We offer a range of adaptable techniques and innovative methods to evaluate the physical and chemical characteristics of any compound. Our highly precise testing and analytical services will improve your production process, expedite R&D and help you conquer any technical challenge.

About

A Global Scientific Services Company

One of the most respected names in contract research and testing, EAG Laboratories is a global scientific services company operating at the intersection of science, technology and…

One of the most respected names in contract research and testing, EAG Laboratories is a global scientific services company operating at the intersection of science, technology and business. The scientists and engineers of EAG apply multi-disciplinary expertise, advanced analytical techniques and “we know how” resolve to answer complex questions that drive commerce around the world.

Our Customers

Science and technology transcend industry boundaries, and so does demand for EAG’s expertise. We partner with companies across a broad spectrum of high-tech, high-impact and…

Science and technology transcend industry boundaries, and so does demand for EAG’s expertise. We partner with companies across a broad spectrum of high-tech, high-impact and highly regulated industries. We help our customers innovate new and improved products, investigate manufacturing problems, perform advanced analyses to determine safety, efficacy and regulatory compliance, and protect their brands.

Our Company Culture

EAG’s corporate culture is firmly rooted in four guiding principles: “foster a growth mindset,” “find a better way,” “earn more loyal customers,” and “win…

EAG’s corporate culture is firmly rooted in four guiding principles: “foster a growth mindset,” “find a better way,” “earn more loyal customers,” and “win together.” Across all of our 20+ locations, you will find a true passion for science and the power of science to improve the world we live in. Hear what some of our ~1200 scientists, engineers and support personnel say about what it means to be part of EAG Laboratories.

Careers

EAG is growing, and we are always looking for talented, problem-solving oriented individuals to join our company. If you have a “we know how” spirit, we want to hear from you.…

EAG is growing, and we are always looking for talented, problem-solving oriented individuals to join our company. If you have a “we know how” spirit, we want to hear from you. Browse current openings now, and re-visit our careers page often.

How do you make continuous improvement profitable?

X-ray Diffraction (XRD) Services

TECHNIQUE NOTE

TYPICAL DATA

XRD has a very wide range of applications, across many sample types and materials. Please see our XRD application notes for more specific examples. A typical XRD application is phase-ID. Shown below is the diffraction pattern from a TiO2 sample. The XRD results show that the sample contains both the Rutile (31.4%) and Anatase (68.6%) phases of TiO2. Compositional results would (ideally) show a 2:1 ratio of O:Ti, but these different phases of TiO2 have different physical and electronic properties so knowing which phase is present can be crucial.

Rutile and Anatase blend

XRD Phase Analysis of titanium oxide (TiO2). The TiO2 consists of 31.4% Rutile and 68.6% Anatase phases.

PRINCIPLES

In XRD analysis a sample is exposed to a collimated X-ray beam of specific known wavelength. If the material is crystalline, it possesses a three dimensional ordering or “structure” with repeat units of atomic arrangement (unit cells). X-rays are diffracted by the repeating lattice spacings of crystalline materials, whereas they are simply scattered by amorphous materials. X-ray diffraction occurs at specific angles (2θ) with respect to the lattice spacings defined by Bragg’s Law:

nλ = 2d sinθ

where n is an integer denoting the order of the reflection, λ is the X-ray wavelength, d is the lattice spacing of the crystal planes of interest, and θ is the diffraction angle. Any change or difference in lattice spacing results in a corresponding shift in the diffraction lines. Consequently, the X-ray diffraction pattern is the fingerprint of periodic atomic arrangements in a given material. Diffraction patterns can be checked against large libraries of patterns from known materials in order to identify/quantify the phases present in a sample.

COMMON APPLICATIONS

While most other analytical techniques tend to provide elemental or molecular information, XRD provides crystalline information, resulting in many unique applications including:

  • Identification/quantification of crystalline phase
  • Measurement of average crystallite size, strain, or micro-strain effects
  • Percent crystallinity versus amorphous component
  • Texture (orientation): preferred orientation of crystallites
  • Determination of lattice parameters to quantify alloy content
  • Residual Stress – lattice compression or expansion High Resolution XRD (HRXRD) – Epitaxial layer composition, strain in/out of plane
  • SAXS – Small Angle X-ray Scattering for agglomerated particle size and spacing
  • High Temperature X-ray Diffraction – in-situ phase change measurement

STRENGTHS

  • Provides a wealth of unique information about crystalline materials
  • Sample the bulk of material (50µm-1cm depth), or near surface only (50-1000nm) using Grazing Incidence-XRD
  • Able to uniquely identify specific crystalline phases
  • Can measure lattice spacing
  • Can analyze full wafers up to 300mm
  • Minimal or no sample preparation requirements
  • Non destructive, using ambient conditions for all analyses

LIMITATIONS

  • Typical detection limit ~1%
  • Cannot identify amorphous components
  • Limited information with respect to depth (no depth profile, but Grazing Incidence-XRD can be used to increase sensitivity for thin layers)
  • Smallest spot size is ~30µm

TECHNIQUE COMPARISONS

XRD is a good complement to bulk analysis techniques such as Glow Discharge Mass Spectrometry, Inductively Coupled Plasma-Optical Emission Spectroscopy (or Mass Spectrometry), and X-ray Fluorescence. While these other techniques provide compositional information, XRD provides crystalline information helping to provide a more complete characterization of the material. It should be noted that by itself XRD cannot provide unequivocal compositional information because it is possible that a sample may have an amorphous component that cannot be identified by XRD. XRD can be quite powerful when combined with other techniques used for thin film analysis, such as Rutherford Backscattering Spectroscopy, Auger and X-ray Photoelectron Spectroscopy. XRD can provide phase, orientation, and other crystalline information to complement the compositional results from RBS, Auger, or XPS. XRD tends to probe much deeper than these techniques, providing more bulk information unless grazing incidence (GI-XRD) is used to enhance the surface sensitivity of the technique.

XRD AT EAG

EAG has five XRD systems located within our network of labs. Three of our instruments are equipped with optical modules that can be easily exchanged depending on the analysis requirement. This allows us to provide high quality analysis of powders, coatings, thin films, slurries, fabricated parts, or even high-resolution analysis of epitaxial films. Two systems have microbeam X-ray sources, allowing for the analysis of very small samples or specific locations. These tools also have area detectors allowing for complete texture analyses.

DESCRIPTION

X-ray Diffraction (XRD) is a powerful nondestructive technique for characterizing crystalline materials. While most other analytical techniques provide elemental or molecular information from a sample, XRD is unique in providing a wide variety of information on structures, crystalline phases, preferred crystal orientations (texture), and other structural parameters such as crystallite size, percent crystallinity, strain, stress, and crystal defects.