Pharmaceutical particle identification challenges can be difficult to solve. Particulate material commonly shows up in pharmaceutical raw materials, in-process samples, and finished products. Understanding the identity of the species is required to determine root cause and evaluate potential corrective action. We have developed micro-analytical methods using a combination of organic characterization and surface analysis techniques to provide insight into the chemistry.
Particulate matter can exist as inorganic/metallic or organic based. We identify organic particulates using a combination of FTIR microscopy, Raman microscopy, XPS/ESCA, and/or TOF-SIMS.