
Curing Issues with Silicone Adhesive
A client requested assistance to investigate a recurrent issue with the curing failure of a silicone adhesive joint between metal components.
Home » Principles and Strengths of In Vitro Testing
In vitro is the Latin term for “in glass,” meaning that the testing is performed in a container that is outside of a living organism. This testing uses cell-based biological models instead of animals or humans. In vitro efforts help fulfil the FDA’s “3Rs approach” to replace, reduce, and/or refine animal testing.
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In Vitro model systems can be specified to the test sample’s intended use. 2D cell cultures are grown rapidly for high-throughput or multi-sample analysis with minimized variation between treatments. Cell cultures can also be made into 3D tissue models. These models contain differentiated cell layers to physiologically represent complex tissues and evaluate specific endpoints. Using specific geometries, in vitro cell culture models can be used to evaluate simple and complex biological responses.
To assess different biological endpoints, various forms of analytical methods may be implemented. Measurable responses of the in vitro models include cell death, growth inhibition, genetic alterations, changes in surface marker expression and altered metabolism.
A client requested assistance to investigate a recurrent issue with the curing failure of a silicone adhesive joint between metal components.
The analytical evaluation threshold (AET), an important part of the extractables and leachables testing in these studies, needs to be calculated for each instrumental technique.
FIB Circuit Edit provides the ability to quickly perform nano-surgury by cutting traces or adding metal connections at the chip level
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